TRAC is an enabling technology, allowing you to study the expression of multiple genes in many samples, quickly and cost-effectively. As such, it is especially useful for screening and other projects where high sample number and study depth are both essential. The technology also has a wide range of other applications in many experimental systems, as it can be used to measure the expression of any gene where the DNA sequence is known.
TRAC has powerful applications in ADME-Tox drug profiling. In one example, TRAC was used to investigate cytochrome P450 expression in primary human hepatocytes in response to several inducers – find out more.
TRAC has also recently been used to screen ADME-Tox responses in reaction to treatment with cytochrome P450-inducers in rat liver tissue – find out more.
TRAC cancer is multiplex, high-throughput and customizable, making it ideal for research into genetically complex cancers. Researchers at the University of Helsinki have used TRAC to investigate gene expression in human gastric cancer tissue samples and cell lines – find out more.
Recently, Metabolex, a specialist in the treatment of type 2 diabetes, used TRAC to investigate the expression of multiple genes likely to be important during lipid formation and storage. Until now, this experiment had not been contemplated due to resource constraints, prohibitive cost and comparability issues caused by using traditional techniques such as microarrays or qPCR. TRAC provides cost-effective and rapid gene multiplexing with high sample throughput, making this study feasible for the first time – find out more.
Another application of TRAC is to measure gene expression changes as a way to optimize recombinant protein production. As an example, a team at the University of Natural Resources and Applied Life Sciences in Vienna has used TRAC to monitor gene expression of in recombinant P. pastoris strains – find out more.