TRAC for ADME-Tox: Products and services

TRAC is ideal for pre-clinical drug studies, as it allows the ADME-Tox profile of a drug to be investigated in many hundreds of samples, without sacrificing the number of genes being analysed. TRAC is also cost-effective and fast, allowing screening to be carried out very efficiently. Using gene expression to assess ADME-Tox response is especially powerful, as indicated in a recent draft report by the FDA, which recommended its suitability over protein-based methods.

We offer a range of pre-validated TRAC panels for ADME-Tox research in a range of model systems, including rat, humans and dogs. You can:

  • Take advantage of our in-house TRAC sample processing service
  • Work with one of our CRO partners to integrate TRAC into your pre-clinical drug screening workflow

Human ADME-Tox library

Over 6 reference genes and many targets to choose from, including:

  • 14 CYP 450 genes, including all FDA-recommended CYP targets
  • Glucuronosyl Transferases
  • Glutathione Transferases
  • ABC Transporters

Dedicated Human ADME-Tox services using our panels of pre-validated ADME-Tox probes:

  • FAST TRAC  – our in house gene expression service
  • TRAC CYP+  SCREEN – rapid service for early-stage compound screening measuring CYP gene expression
  • TRAC INDUCTION – more in depth compound analysis service for assessing CYP expression and activity profile

Rat ADME-Tox library

More than 120 targets and over 14 reference genes to choose from, including:

  • Markers for hepatotoxicity, necrosis, cholestasis and steatosis
  • Drug metabolism and transport pathways
  • Learn more and see some of the data associated with TRAC rat ADME-Tox probes…

Dog ADME-Tox library

A panel of the most common CYP 450 genes and reference genes for primary hepatocyte induction studies – Learn more